Medication Hepatotoxicity

  • Many medications can cause liver enzyme elevations, chronic hepatitis, cirrhosis, or acute liver failure
  • Acetaminophen (Tylenol) is a common cause of drug-induced liver injury
  • Cholesterol lowering medications (“statins”) cause elevated liver tests in 4% of people but this is rarely associated with significant liver damage
  • Antibiotics, anti-seizure medications are also common causes
  • Onset can be immediately after starting a new medication or after many months of taking a medication
  • Mostly reversible when recognized early
  • Herbal remedies and dietary supplements are also known to cause liver damage, especially body building and weight loss supplements