Primary Sclerosing Cholangitis

  • Uncommon disorder affecting the large and middle-sized bile ducts with scarring
  • Chronic blockage of bile ducts by scarring leads to liver damage
  • Can progress to cirrhosis, liver failure and bile duct cancer
  • Affects men more than women
  • Cause unknown – may be immune-mediated
  • Often associated with ulcerative colitis
  • No effective treatment other than liver transplant